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There Were No Consistent Differences Between MBRP and Any of the Comparators for Substance Use Outcomes

• Overall, the available evidence in support of MBRP is very limited, both in terms of the quantity of existing studies and the quality of the body of evidence.
• The review indicates positive results for MBRP as an adjunctive therapy for health-related quality of life and legal problems; however, given that these results were based on one RCT without replication, there is uncertainty in the magnitude and stability of effect estimates.
• The available evidence on adverse events is also very limited; two RCTs reported no adverse events, while a third reported that one participant receiving standard relapse prevention died, and another participant receiving MBRP was admitted to inpatient care for reasons unknown.
• The overall pattern of the data does not suggest that MBRP is any more efficacious for substance use disorder outcomes than standard treatments, though future trials are needed to provide more firm conclusions about the efficacy and safety of MBRP.