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Eicosapentaenoic Acid (EPA) for Mild and Moderate Depression Might Have a Small Benefit, but the Evidence Base Is Weak

• The review showed that dietary supplements of omega-3 fatty acids may have a small benefit in improving depression symptoms compared with placebo; however, the quality of evidence for this conclusion is weak.
• Subgroup analyses indicated higher efficacy of supplements that contain EPA or higher concentrations of EPA than DHA.
• Benefits compared with placebo were primarily based on monotherapy studies.
• Too few studies assessed effects of omega-3 fatty acids on remission and quality of life to draw conclusions.
• Omega-3 fatty acids were associated with an increased risk for mild gastrointestinal symptoms but not with other categories of adverse events or serious adverse events.