| 来源类型 | Research Reports
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| 规范类型 | 报告
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| DOI | https://doi.org/10.7249/RR1520
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| 来源ID | RR-1520-RE
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| Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts |
| Talitha Dubow; Sonja Marjanovic
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| 发表日期 | 2016
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| 出版年 | 2016
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| 页码 | 78
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| 语种 | 英语
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| 结论 |
- Population-based sequencing initiatives have diverse goals, but are increasingly focused on clinical application.
- Population-based sequencing initiatives have had direct impacts on biomedicine as a field, as well as contributing to the social institutions that govern science and innovation more widely.
- Direct achievements of population-based sequencing initiatives include: catalogues of population-specific genetic variation that have enabled clinical association studies; longitudinal datasets that can enhance our understanding of the links between genetic, lifestyle and environmental factors; enhanced prospects for diagnosis and improved disease-management; and contributions to research and innovation capacity-building (e.g. new analytical tools, skills, equipment and facilities).
- Population-sequencing initiatives have advanced the state of debate on research ethics and data management, and introduced new approaches to addressing the accompanying social concerns, such as informed consent and privacy and security provisions.
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| 摘要 |
Based on our analysis, we recommend five areas for consideration by policymakers and researchers alike:
- Scale-up of international, interdisciplinary and cross-sector collaboration;
- New research on the implications of genomic interventions in a clinical setting;
- Possible changes in the rationales for public and private investment in genomic medicine and in industry R&D models, as well as associated public acceptability concerns accompanying the joint pursuit of health and commercial interests;
- Consolidation of learning regarding appropriate research ethics arrangements, and consideration of necessary legal frameworks;
- Wider evaluation and learning from past and present efforts.
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| 主题 | Bioethics
; Genomic Medicine
; Health Care Technology
; Populations
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| URL | https://www.rand.org/pubs/research_reports/RR1520.html
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| 来源智库 | RAND Corporation (United States)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/108270
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推荐引用方式
GB/T 7714 |
Talitha Dubow,Sonja Marjanovic. Population-scale sequencing and the future of genomic medicine: Learning from past and present efforts. 2016.
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