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The Official Disability Guidelines (ODG) Medical Treatment Guidelines received overall favorable ratings from expert clinicians on content related to common occupational conditions, despite notable limitations to the methods used to develop the guidelines. ODG's strengths include an expansive scope, clearly written recommendations, frequent updating, regular and extensive input from clinicians, and a well-designed tool for applying recommendations. Weaknesses include limited input from workers with occupational conditions, inadequate information about the process by which evidence is identified and synthesized, and lack of documentation that ODG chapter development teams were free of conflicts of interest and had editorial independence. Of note, however, expert panelists in diverse clinical specialties found material related to 41 of the 47 topics that they considered in the ODG to be clinically valid, reflecting a relatively high degree of confidence in the clinical acceptability of the guideline. For the six remaining topics, including medications and nonoperative procedures for neck and upper back injuries as well as nonoperative procedures for hip injuries, content was of uncertain validity. Several panelists also noted that the evidence basis for numbers of allowed physical therapy sessions was uncertain.