G2TT
来源类型Research Reports
规范类型报告
DOIhttps://doi.org/10.7249/RR2108
来源IDRR-2108-OSD
Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review
Margaret A. Maglione; Laura Raaen; Christine Chen; Gulrez Shah Azhar; Nima Shahidinia; Mimi Shen; Ervant J. Maksabedian Hernandez; Roberta M. Shanman; Susanne Hempel
发表日期2018
出版年2018
页码273
语种英语
结论

A comprehensive literature search that screened over 6,000 research citations on the topic identified only 27 randomized controlled trials and ten observational studies that reported on functional outcomes

  • No randomized control trial was rated as high quality, but several observational studies were methodologically sound.
  • The only functional measures reported in more than one study were verbal memory, attention, insomnia, fatigue, and criminal activity.
  • MAT users had twice the risk of injurious traffic accidents than nonusers, according to one large observational study.
  • Based on two studies, it appears that MAT users do not perform worse on verbal memory tasks than healthy controls.
  • One study showed that patients taking buprenorphine or methadone scored higher in aggressive responding than healthy controls.

Evidence was mixed when MAT patients were compared with persons with OUD who were not on MAT

  • One cohort comparison found that fewer buprenorphine patients reported fatigue than did persons with OUD who did not receive MAT; other physical and behavioral/social function outcomes had mixed findings or showed no differences.

There was little statistically robust evidence that treatment effects systematically vary by medication

  • A comparison across randomized controlled trials found a significantly lower prevalence of fatigue in buprenorphine patients compared with methadone patients.

Direct comparisons of functional effects by route of administration, length of treatment, and treatment modality were scarce and reported mixed results and pointed to important research gaps that should be addressed in future studies

摘要
  • Clinicians and policy makers should use this comprehensive review summarizing the research evidence on functional outcomes when making recommendations for practice and policy.
  • The report outlines concrete suggestions for research funding agencies that describe the studies needed to support strong conclusions about the effects of MAT on functional outcomes, potential differences among medication types, the role of treatment modalities, and the effect of the length of treatment. Some studies that compared MAT patients to persons with OUD who did not receive MAT reported significant beneficial effects. However, this finding does not imply that performance meets the standards required for military deployment.
主题Military Health and Health Care ; Opioids ; Pharmaceutical Drugs ; Substance Abuse Treatment
URLhttps://www.rand.org/pubs/research_reports/RR2108.html
来源智库RAND Corporation (United States)
引用统计
资源类型智库出版物
条目标识符http://119.78.100.153/handle/2XGU8XDN/108917
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GB/T 7714
Margaret A. Maglione,Laura Raaen,Christine Chen,et al. Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review. 2018.
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