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Details how the factors that drove clinical use of high-dose chemotherapy with autologous bone marrow transplantation (HDC/ABMT)-patient demand, physician enthusiasm, media reporting, litigation, and administrative mandates-converged to propel the procedure forward despite a lack of proven clinical effectiveness. False Hope also analyzes the failure of the technology assessments and randomized clinical trials that evaluated the procedure and the ramifications of this flawed system on health care today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section addresses the significance of the story for our health care system.