G2TT
来源类型Monograph (IIASA Interim Report)
规范类型报告
Conservation of the Segmented Germband Stage: Robustness or Pleiotropy?
Galis F; Van Dooren TJM; Metz JAJ
发表日期2002
出版者IIASA, Laxenburg, Austria: IR-02-050
出版年2002
语种英语
摘要Gene expression patterns of the segment polarity genes in the extended and segmented germband stage are remarkably conserved among insects. To explain the conservation of these stages, two hypotheses have been proposed. One hypothesis states that the conservation reflects a high interactivity between modules, so that mutations would have several pleiotropic effects in other parts of the body, resulting in stabilizing selection against mutational variation. The other hypothesis states that the conservation is caused by robustness of the segment polarity network against mutational changes. When evaluating the empirical evidence for these hypotheses, we found strong support for pleiotropy and little evidence supporting robustness of the segment polarity network. This points to a key role for stabilizing selection in the conservation of these stages. Finally, we discuss the implications for robustness of organizers and long-term conservation in general.
主题Adaptive Dynamics Network (ADN)
关键词Robustness Modularity Pleiotropy Stabilizing-selection Phylotypic stage Extended and segmented germband Organizers
URLhttp://pure.iiasa.ac.at/id/eprint/6735/
来源智库International Institute for Applied Systems Analysis (Austria)
资源类型智库出版物
条目标识符http://119.78.100.153/handle/2XGU8XDN/125155
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Galis F,Van Dooren TJM,Metz JAJ. Conservation of the Segmented Germband Stage: Robustness or Pleiotropy?. 2002.
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