G2TT
来源类型Monograph (IIASA Interim Report)
规范类型报告
Optimal Phosphorylation Step Number of Intracellular Signal Transduction Pathway.
Nakabayashi J; Sasaki A
发表日期2005
出版者IIASA, Laxenburg, Austria: IR-05-081
出版年2005
语种英语
摘要Eukaryotic cells use signal transduction network to respond in specific ways to external signals from their environment. Several signal transduction pathway are composed of multi-step chemical reactions. We here theoretically study what determines the number of kinase phosphorylation steps composing of the intracellular signal transduction cascade. We examine a simple mathematical model for the association and phosphorylation process of kinases in the signal transduction cascade. We focus on the speed of signal transduction as the criterion for determining the optimal response. The present model first reveals that the initial expression level of kinase in each step of the cascade must be the same in the optimal response under the constraint of the constant total kinase concentration. The second conclusion is that the optimal step number of kinase cascade is primarily determined by the ratio of the target concentration of the final phosphorylated kinase in the cascade to that of input signal molecule, C/S. A multi-step phosphorylation can be optimal when the amplification of the final product concentration C relative to the input signal S is sufficiently large. This suggests that multi-step phosphorylation would have evolved to accelerate the speed of transduction of weak signals.
主题Adaptive Dynamics Network (ADN)
URLhttp://pure.iiasa.ac.at/id/eprint/7761/
来源智库International Institute for Applied Systems Analysis (Austria)
资源类型智库出版物
条目标识符http://119.78.100.153/handle/2XGU8XDN/125393
推荐引用方式
GB/T 7714
Nakabayashi J,Sasaki A. Optimal Phosphorylation Step Number of Intracellular Signal Transduction Pathway.. 2005.
条目包含的文件
文件名称/大小 资源类型 版本类型 开放类型 使用许可
IR-05-081.pdf(233KB)智库出版物 限制开放CC BY-NC-SA浏览
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Nakabayashi J]的文章
[Sasaki A]的文章
百度学术
百度学术中相似的文章
[Nakabayashi J]的文章
[Sasaki A]的文章
必应学术
必应学术中相似的文章
[Nakabayashi J]的文章
[Sasaki A]的文章
相关权益政策
暂无数据
收藏/分享
文件名: IR-05-081.pdf
格式: Adobe PDF
此文件暂不支持浏览

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。