| 来源类型 | Monograph (IIASA Interim Report) |
| 规范类型 | 报告 |
| Evolution of DNA Double-Strand Break Repair by Gene Conversion: Coevolution Between a Phage and Restriction-Modification System. | |
| Yahara K; Horie R; Kobayashi I; Sasaki A | |
| 发表日期 | 2007 |
| 出版者 | IIASA, Laxenburg, Austria: IR-07-060 |
| 出版年 | 2007 |
| 语种 | 英语 |
| 摘要 | The necessity to repair genome damage has been considered to be an immediate factor responsible for the origin of sex. Indeed, attack by a cellular restriction enzyme of invading DNA from several bacteriophages initiates recombinational repair by gene conversion if there is homologous DNA. In the present work, we modeled the interaction between a bacteriophage and a bacterium carrying a restriction enzyme as antagonistic coevolution. We assume a locus on the bacteriophage genome has either a restriction-sensitive or a -resistant allele, and another locus determines whether it is recombination/repair-proficient or -defective. A restriction break can be repaired by a co-infecting phage genome if one of them is recombination/repair-proficient. We define the fitness of phage (resistant/sensitive and repair-positive/-negative) genotypes and bacterial (restriction-positive/-negative) genotypes by assuming random encounter of the genotypes, with a given probabilities of single and double infections, and the costs of resistance, repair and restriction. Our results show the evolution of the repair allele depends on b1 / b0 , the ratio of the burst size b1 under damage to host cell physiology induced by an unrepaired double-strand break to the default burst size b0 . It was not until this effect was taken into account that the evolutionary advantage of DNA repair became apparent. |
| 主题 | Evolution and Ecology (EEP) |
| URL | http://pure.iiasa.ac.at/id/eprint/8398/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/125564 |
| 推荐引用方式 GB/T 7714 | Yahara K,Horie R,Kobayashi I,et al. Evolution of DNA Double-Strand Break Repair by Gene Conversion: Coevolution Between a Phage and Restriction-Modification System.. 2007. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| IR-07-060.pdf（182KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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