| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1016/S0168-9525(02)02739-7 |
| Conservation of the segmented germband stage: Robustness or pleiotropy? | |
| Galis F; Van Dooren TJM; Metz JAJ | |
| 发表日期 | 2002 |
| 出处 | Trends in Genetics 18 (10): 504-509 |
| 出版年 | 2002 |
| 语种 | 英语 |
| 摘要 | Gene expression patterns of the segment polarity genes in the extended and segmented germband stage are remarkably conserved among insects. To explain the conservation of these stages, two hypotheses have been proposed. One hypothesis states that the conservation reflects a high interactivity between modules, so that mutations would have several pleiotropic effects in other parts of the body, resulting in stabilizing selection against mutational variation. The other hypothesis states that the conservation is caused by robustness of the segment polarity network against mutational changes. When evaluating the empirical evidence for these hypotheses, we found strong support for pleiotropy and little evidence supporting robustness of the segment polarity network. This points to a key role for stabilizing selection in the conservation of these stages. Finally, we discuss the implications for robustness of organizers and long-term conservation in general. |
| 主题 | Adaptive Dynamics Network (ADN) |
| 关键词 | Robustness Modularity Pleiotropy Stabilizing-selection Phylotypic stage Extended and segmented germband Organizers |
| URL | http://pure.iiasa.ac.at/id/eprint/6532/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/128090 |
| 推荐引用方式 GB/T 7714 | Galis F,Van Dooren TJM,Metz JAJ. Conservation of the segmented germband stage: Robustness or pleiotropy?. 2002. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
