| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1111/j.0014-3820.2006.tb01896.x |
| Extreme selection in humans against homeotic transformations of cervical vertebrae. | |
| Galis F; Van Dooren TJM; Feuth JD; Metz JAJ; Witkam A; Ruinard S; Steigenga MJ; Wijnaendts LCD | |
| 发表日期 | 2006 |
| 出处 | Evolution 60 (12): 2643-2654 |
| 出版年 | 2006 |
| 语种 | 英语 |
| 摘要 | Why do all mammals, except for sloths and manatees, have exactly seven cervical vertebrae? In other vertebrates and other regions, the vertebral number varies considerably. We investigated whether natural selection constrains the number of cervical vertebrae in humans To this end, we determined the incidence of cervical ribs and other homeotic vertebral changes in radiographs of deceased human fetuses and infants, and analyzed several existing datasets on the incidence in infants and adults. Our data show that homeotic transformations that change the number of cervical vertebrae are extremely common in humans, but are strongly selected against: almost all individuals die before reproduction. Selection is most probably indirect, caused by a strong coupling of such changes with major congenital abnormalities. Changes in the number of thoracic vertebrae appear to be subject to weaker selection, in good correspondence with the weaker evolutionary constraint on these numbers. Our analysis highlights the role of prenatal selection in the conservation of our common body plan. |
| 主题 | Evolution and Ecology (EEP) |
| 关键词 | Developmental constraint, evolutionary medicine, Hox genes, left-right asymmetry, modularity, phylotypic stage, pleiotropy |
| URL | http://pure.iiasa.ac.at/id/eprint/7868/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/128548 |
| 推荐引用方式 GB/T 7714 | Galis F,Van Dooren TJM,Feuth JD,et al. Extreme selection in humans against homeotic transformations of cervical vertebrae.. 2006. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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