| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1073/pnas.0908404106 |
| Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer. | |
| Yahara K; Fukuyo M; Sasaki A; Kobayashi I | |
| 发表日期 | 2009 |
| 出处 | Proceedings of the National Academy of Sciences 106 (44): 18861-18866 |
| 出版年 | 2009 |
| 语种 | 英语 |
| 摘要 | Homing endonuclease genes are "selfish" mobile genetic elements whose endonuclease promotes the spread of its own gene by creating a break at a specific target site and using the host machinery to repair the break by copying and inserting the gene at this site. Horizontal transfer across the boundary of a species or population within which mating takes place has been thought to be necessary for their evolutionary persistence. This is based on the assumption that they will become fixed in a host population, where opportunities of homing will disappear, and become susceptible to degeneration. To test this hypothesis, we modeled behavior of a homing endonuclease gene that moves during meiosis through double-strand break repair. We mathematically explored conditions for persistence of the homing endonuclease gene and elucidated their parameter dependence as phase diagrams. We found that, if the cost of the pseudogene is lower than that of the homing endonuclease gene, the 2 forms can persist in a population through autonomous periodic oscillation. If the cost of the pseudogene is higher, 2 types of dynamics appear that enable evolutionary persistence: bistability dependent on initial frequency or fixation irrespective of initial frequency. The prediction of long persistence in the absence of horizontal transfer was confirmed by stochastic simulations in finite populations. The average time to extinction of the endonuclease gene was found to be thousands of meiotic generations or more based on realistic parameter values. These results provide a solid theoretical basis for an understanding of these and other extremely selfish elements. |
| 主题 | Evolution and Ecology (EEP) |
| 关键词 | Haploid-diploid cycle Horizontal gene transfer Meiosis Selfish gene VDE |
| URL | http://pure.iiasa.ac.at/id/eprint/8792/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/128910 |
| 推荐引用方式 GB/T 7714 | Yahara K,Fukuyo M,Sasaki A,et al. Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer.. 2009. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Evolutionary%20maint（479KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
