| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1098/rspb.2010.0519 |
| Ecological factors driving the long-term evolution of influenza's host range. | |
| Cobey S; Pascual M; Dieckmann U | |
| 发表日期 | 2010 |
| 出处 | Proceedings of the Royal Society B: Biological Sciences 277 (1695): 2803-2810 |
| 出版年 | 2010 |
| 语种 | 英语 |
| 摘要 | The evolution of a pathogen's host range is shaped by the ecology of its hosts and by the physiologicl traits that determine host specificity. For many pathogen traits, there is a trade-off: a phenotype suitable for infecting one set of hosts poorly infects another. Introducing and analysing a simple evo-epidemiological model, here we study how such a trade-off is expected to affect evolution of the host ranges of influenza viruses. We examine a quantitative trait underlying host specificity, given by an influenza virus's degree of adaptation to certain conformations of sialic acid receptors, and investiate how this receptor preference evolves in a minimal network of host species, including humans, that differ in life history and receptor physiology. Using adaptive dynamics theory, we establish thresholds in interspecific transmission rates and host population sizes that govern the emergence and persistence of human-adapted viruses. These ecological thresholds turn out to be largely independent of the strength of the evolutionary trade-off, underscoring the importance of ecological conditions in determining a disease's host range. |
| 主题 | Evolution and Ecology (EEP) |
| 关键词 | Adaptive dynamics Emerging infectious diseases Host range Influenza |
| URL | http://pure.iiasa.ac.at/id/eprint/9193/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/129087 |
| 推荐引用方式 GB/T 7714 | Cobey S,Pascual M,Dieckmann U. Ecological factors driving the long-term evolution of influenza's host range.. 2010. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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