| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1038/srep00238 |
| Success of a suicidal defense strategy against infection in a structured habitat. | |
| Fukuyo M; Sasaki A; Kobayashi I | |
| 发表日期 | 2012 |
| 出处 | Scientific Reports 2: no.238 |
| 出版年 | 2012 |
| 语种 | 英语 |
| 摘要 | Pathogen infection often leads to the expression of virulence and host death when the host-pathogen symbiosis seems more beneficial for the pathogen. Previously proposed explanations have focused on the pathogen's side. In this work, we tested a hypothesis focused on the host strategy. If a member of a host population dies immediately upon infection aborting pathogen reproduction, it can protect the host population from secondary infections. We tested this "Suicidal Defense Against Infection" (SDAI) hypothesis by developing an experimental infection system that involves a huge number of bacteria as hosts and their virus as pathogen, which is linked to modeling and simulation. Our experiments and simulations demonstrate that a population with SDAI strategy is successful in the presence of spatial structure but fails in its absence. The infection results in emergence of pathogen mutants not inducing the host suicide in addition to host mutants resistant to the pathogen. |
| 主题 | Evolution and Ecology (EEP) |
| 关键词 | Computational biology Evolution Population genetics Microbiology |
| URL | http://pure.iiasa.ac.at/id/eprint/9968/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/129402 |
| 推荐引用方式 GB/T 7714 | Fukuyo M,Sasaki A,Kobayashi I. Success of a suicidal defense strategy against infection in a structured habitat.. 2012. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| srep00238.pdf（1563KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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