| 来源类型 | Article
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| 规范类型 | 其他
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| DOI | 10.1016/j.jtbi.2013.03.027
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| Timing of the emergence of new successful viral strains in seasonal influenza. |
| Omori R; Sasaki A
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| 发表日期 | 2013
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| 出处 | Journal of Theoretical Biology : 32-38
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| 出版年 | 2013
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| 语种 | 英语
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| 摘要 | High evolvability of influenza virus and the complex nature of its antagonistic interaction with the host immune system make it difficult to predict which strain of virus will become epidemic next and when it will emerge. To investigate the most likely time at which a new successful strain emerges every year in seasonal influenza, we use an individual-based model that takes into account the seasonality in transmission rate and host cross-immunity against a current viral strain due to previous infections with other strains. Our model deals with antigenic evolution of influenza virus that originated by point mutations at amino acid sites that constitute epitope and is driven by host immune response. Under the range of parameters by which influenza virus shows a "trunk" shape in its phylogenetic tree, as is typical in influenza A virus evolution, we find that most successful mutant strains emerge in an early part of the epidemic season, and that the time when the number of infected hosts reaches a maximum tends to be more than one season after viral emergence. This carryover of the epidemic peak timing implies that we can predict the strain that will become dominant in the epidemic in the following year. |
| 主题 | Evolution and Ecology (EEP)
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| 关键词 | Antigenic drift
Cross-immunity
Epidemiology
Evolution
SIR model
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| URL | http://pure.iiasa.ac.at/id/eprint/10399/
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| 来源智库 | International Institute for Applied Systems Analysis (Austria)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/129730
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推荐引用方式
GB/T 7714 |
Omori R,Sasaki A. Timing of the emergence of new successful viral strains in seasonal influenza.. 2013.
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