| 来源类型 | Article
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| 规范类型 | 其他
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| DOI | 10.1038/srep10015
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| Physiologically motivated multiplex Kuramoto model describes phase diagram of cortical activity. |
| Sadilek M; Thurner S
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| 发表日期 | 2015
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| 出处 | Scientific Reports 5: no.10015
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| 出版年 | 2015
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| 语种 | 英语
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| 摘要 | We derive a two-layer multiplex Kuramoto model from Wilson-Cowan type physiological equations that describe neural activity on a network of interconnected cortical regions. This is mathematically possible due to the existence of a unique, stable limit cycle, weak coupling, and inhibitory synaptic time delays. We study the phase diagram of this model numerically as a function of the inter-regional connection strength that is related to cerebral blood flow, and a phase shift parameter that is associated with synaptic GABA cncentrations. We find three macroscopic phases of cortical activity: background activity (unsynchronized oscillations), epileptiform activity (highly synchronized oscillations) and resting-state activity (synchronized clusters/chaotic behaviour). Previous network models could hithero not explain the existence of all three phases. We further observe a shift of the average oscillation frequency towards lower values together with the appearance of coherent slow oscillations at the transition from resting-state to epileptiform activity. This observation is fully in line with experimental data and could explain the influence of GABAergic drugs both on gamma oscillations and epileptic states. Compared to previous models for gamma oscillations and resting-state activity, the multiplex Kuramoto model not only provides a unifying framework, but also has a direct connection to measurable physiological parameters. |
| 主题 | Advanced Systems Analysis (ASA)
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| URL | http://pure.iiasa.ac.at/id/eprint/11438/
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| 来源智库 | International Institute for Applied Systems Analysis (Austria)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/130242
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推荐引用方式
GB/T 7714 |
Sadilek M,Thurner S. Physiologically motivated multiplex Kuramoto model describes phase diagram of cortical activity.. 2015.
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文件名：
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srep10015.pdf
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Adobe PDF
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