| 来源类型 | Article |
| 规范类型 | 其他 |
| DOI | 10.1016/j.jtbi.2017.04.025 |
| Analysis of stability to cheaters in models of antibiotic degrading microbial communities. | |
| Szilágyi A; Boza G; Scheuring I | |
| 发表日期 | 2017 |
| 出处 | Journal of Theoretical Biology 423: 53-62 |
| 出版年 | 2017 |
| 语种 | 英语 |
| 摘要 | Antibiotic resistance carried out by antibiotic degradation has been suggested recently as a new mechanism to maintain coexistence of microbial species competing on a single limiting resource, even in well-mixed homogeneous environments. Species diversity and community stability, however, critically depend on resistance against social cheaters, mutants that do not invest in production, but still enjoy the benefits provided by others. Here we investigate how different mutant cheaters affect the stability of antibiotic producing and degrading microbial communities. We consider two cheater types, production and degradation cheaters. We generalize the mixed inhibition-zone and chemostat models introduced previously [Kelsic, E. D., Zhao, J., Vetsigian, K., Kishony, R., 2015. Counteraction of an tibiotic production and degradation stabilizes microbial communities. Nature521, 516–519.] to study the population dynamics of microbial communities in well-mixed environment, and analyze the invasion of different cheaters in these models. We show that production cheaters, mutants that cease producing antibiotics, always destroy coexistence whenever there is a cost of producing these antibiotics. Degradation cheaters, mutants that loose their function of producing extracellular antibiotic degrading molecules, induce community collapse only if the cost of producing the degradation factors is above a critical level. Our analytical studies, supported by numerical simulations, highlight the sensitivity of antibiotic producing and degrading communities to loss-of-function mutants. |
| 主题 | Evolution and Ecology (EEP) ; Risk & ; Resilience (RISK) ; Risk, Policy and Vulnerability (RPV) |
| 关键词 | Rock-paper-scissors Social parasite Evolutionary instability Antibiotic-mediated microbiome Degradation resistance |
| URL | http://pure.iiasa.ac.at/id/eprint/14549/ |
| 来源智库 | International Institute for Applied Systems Analysis (Austria) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/130852 |
| 推荐引用方式 GB/T 7714 | Szilágyi A,Boza G,Scheuring I. Analysis of stability to cheaters in models of antibiotic degrading microbial communities.. 2017. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| analysis-stability-c（608KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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