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This paper provides an overview of the likely impacts of climate change in three least developed countries in East Africa: Sudan, Tanzania and Uganda. In the coming decades, climate change is likely to alter temperatures and distribution of rainfall, contribute to sea-level rise and increase the frequency and intensity of extreme weather events in East Africa. As a result, climate change has the potential to undermine, and even undo, socio-economic development in East Africa and it is imperative that governments and institutions come together to formulate long-term adaptation strategies.