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The paper is a study to describe the role of climate (observed climate warming, and climate variability) on malaria in Uganda. The study was conducted in Kabale district , in highland malaria. The finding of the study showed that Malaria cases have increased over the years in Kabale district. There is a slight but steady increase in both minimum and maximum average monthly temperatures that correspond to an increase I prevalence of malaria cases. However, it was difficult to tell from this study or clearly determine the relationship between rainfall and malaria. Although mosquito opulations increase with rain and malaria cases are expected to do the same. What appears important is the mosquito bleeding sites, which can be facilitated by rains. The study recommends that there is need therefore to develop a multi-institutional research network to better understand climate change and its health, social and economic consequences, as well as develop health risk scenarios periodically using the best available information on climate change anticipated in different ecosystems and assess the potential health risks associated with changes in the country.