全球智库信息集成服务系统(G2TT): Big Pharma, little science? A bibliometric perspective on Big Pharma’s R&D decline.

G2TT

来源类型	Article
规范类型	其他
DOI	10.1016/j.techfore.2012.06.007
ISBN	0040-1625
	Big Pharma, little science? A bibliometric perspective on Big Pharma’s R&D decline.
	Rafols, Ismael; Hopkins, Michael M; Hoekman, Jarno; Siepel, Josh; O'Hare, Alice; Perianes-Rodríguez, Antonio; Nightingale, Paul
发表日期	2014-01
出处	Technological Forecasting and Social Change
出版者	Elsevier
出版年	2014
页码	22-38
语种	英语
摘要	There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D laboratories of the major European and US pharmaceutical firms during the period 1995–2009. The empirical findings present an industry in transformation. In the first place, we observe a decline of the total number of publications by large firms. Second, we show a relative increase of their external collaborations suggesting a tendency to outsource, and a diversification of the disciplinary base, in particular towards computation, health services and more clinical approaches. Also evident is a more pronounced decline in publications by both R&D laboratories located in Europe and by firms with European headquarters. Finally, while publications by Big Pharma in emerging economies sharply increase, they remain extremely low compared with those in developed countries. In summary, the trend in this transformation is one of a gradual decrease in internal research efforts and increasing reliance on external research. These empirical insights support the view that large pharmaceutical firms are increasingly becoming ‘network integrators’ rather than the prime locus of drug discovery.
特色分类	H Social Sciences (General)
URL	http://sro.sussex.ac.uk/id/eprint/39784/
来源智库	Science Policy Research Unit (United Kingdom)
引用统计
资源类型	智库出版物
条目标识符	http://119.78.100.153/handle/2XGU8XDN/468264
推荐引用方式 GB/T 7714	Rafols, Ismael,Hopkins, Michael M,Hoekman, Jarno,等. Big Pharma, little science? A bibliometric perspective on Big Pharma’s R&D decline.. 2014.