| 来源类型 | Article
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| 规范类型 | 其他
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| DOI | 10.1016/j.respol.2016.12.001
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| ISBN | 0048-7333
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| Testing regimes in clinical trials: evidence from four polio vaccine trajectories. |
| Yaqub, Ohid
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| 发表日期 | 2017-03-01
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| 出处 | Research Policy
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| 出版者 | Elsevier
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| 出版年 | 2017
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| 页码 | 475-484
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| 语种 | 英语
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| 摘要 | This paper highlights distinctive features of a neglected class of economic activity in the domain of medical innovation, namely the creation of testing regimes in clinical trials, asking how their nature might be expected to affect innovation of medical technology. It argues firstly that clinical trials are not simply about passively validating an already well-known technology and verifying its safety. Rather, clinical trials are part of a more active process of learning that allows pharmaceutical innovations to be useful outside the laboratory. It argues secondly that product development can proceed along a number of long and costly paths before a product’s behaviour in actual practice becomes clear, which can make selecting between alternative courses of action difficult. Thus, product choice and product development need to go hand-in-hand. To consider these arguments, the paper maps out four trajectories of polio vaccine development, tracing their paths through clinical trials since the 1950s, and describes some of the defining features of testing regimes for medical innovation. These include institutions that integrate knowledge and co-ordinate skills in testing processes, and capabilities for allocating testing resources, managing testability constraints, sharing knowledge and improving commensurability between testing communities. |
| 关键词 | Medical innovation, health, vaccine, research policy, research governance
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| URL | http://sro.sussex.ac.uk/id/eprint/65842/
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| 来源智库 | Science Policy Research Unit (United Kingdom)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/468867
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推荐引用方式
GB/T 7714 |
Yaqub, Ohid. Testing regimes in clinical trials: evidence from four polio vaccine trajectories.. 2017.
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文件名：
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polio trajectories final RP.pdf
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格式：
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Adobe PDF
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