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Increasingly, researchers and practitioners recognize the need for neighborhood revitalization policies that improve conditions in neighborhoods where low-income and minority households are concentrated. Although there is a rich literature describing past efforts to revitalize distressed neighborhoods, this literature provides little concrete guidance for todays policymakers. This What Works framing paper focuses on basic neighborhood improvement strategies and the specific mechanisms at work that provide levers for revitalization. The paper lays out strategies for neighborhood revitalization focusing on strengthening community-level and city-wide institutions to support and reinforce success, and regional strategies for equitable housing and community development. This framing paper is part of a series of field-building research agendas produced under the What Works Collaborative. More information can be found on the What Works Collaborative web page