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来源类型 | Publication |
The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency | |
Sonya Cressman; Stuart J. Peacock; Martin C. Tammemä; gi; William K. Evans; Natasha B. Leighl; John R. Goffin; Alain Tremblay; Geoffrey Liu; Daria Manos; Paul MacEachern; Rick Bhatia; Serge Puksa; Garth Nicholas; Annette McWilliams; John R. Mayo; John Yee; John C. English; Reka Pataky; Emily McPherson; Sukhinder Atkar-Khattra; Michael R. Johnston; Heidi Schmidt; Frances A. Shepherd; Kam Soghrati; Kayvan Amjadi; Paul Burrowes; Christian Couture; Harmanjatinder S. Sekhon; Kazuhiro Yasufuku; Glenwood Goss; Diana N. Ionescu; David M. Hwang; Simon Martel; Don D. Sin; Wan C. Tan; Stefan Urbanski; Zhaolin Xu; Ming-Sound Tsao; and Stephen Lam | |
发表日期 | 2017-08-01 |
出版者 | Journal of Thoracic Oncology, vol. 12, no. 8 |
出版年 | 2017 |
语种 | 英语 |
概述 | Lung cancer risk prediction models have the potential to make programs more affordable; however, the economic evidence is limited.", |
摘要 | Lung cancer risk prediction models have the potential to make programs more affordable; however, the economic evidence is limited. Participants in the National Lung Cancer Screening Trial (NLST) were retrospectively identified with the risk prediction tool developed from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. The high-risk subgroup was assessed for lung cancer incidence and demographic characteristics compared with those in the low-risk subgroup and the Pan-Canadian Early Detection of Lung Cancer Study (PanCan), which is an observational study that was high-risk–selected in Canada. A comparison of high-risk screening versus standard care was made with a decision-analytic model using data from the NLST with Canadian cost data from screening and treatment in the PanCan study. Probabilistic and deterministic sensitivity analyses were undertaken to assess uncertainty and identify drivers of program efficiency. Use of the risk prediction tool developed from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial with a threshold set at 2% over 6 years would have reduced the number of individuals who needed to be screened in the NLST by 81%. High-risk screening participants in the NLST had more adverse demographic characteristics than their counterparts in the PanCan study. High-risk screening would cost $20,724 (in 2015 Canadian dollars) per quality-adjusted life-year gained and would be considered cost-effective at a willingness-to-pay threshold of $100,000 in Canadian dollars per quality-adjusted life-year gained with a probability of 0.62. Cost-effectiveness was driven primarily by non–lung cancer outcomes. Higher noncurative drug costs or current costs for immunotherapy and targeted therapies in the United States would render lung cancer screening a cost-saving intervention. Non–lung cancer outcomes drive screening efficiency in diverse, tobacco-exposed populations. Use of risk selection can reduce the budget impact, and screening may even offer cost savings if noncurative treatment costs continue to rise. |
URL | https://www.mathematica.org/our-publications-and-findings/publications/the-cost-effectiveness-of-high-risk-lung-cancer-screening-and-drivers-of-program-efficiency |
来源智库 | Mathematica Policy Research (United States) |
资源类型 | 智库出版物 |
条目标识符 | http://119.78.100.153/handle/2XGU8XDN/488964 |
推荐引用方式 GB/T 7714 | Sonya Cressman,Stuart J. Peacock,Martin C. Tammemä,et al. The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency. 2017. |
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