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This report discusses the challenges in measuring self-regulation skills and provides guidance on selecting measures to use in evaluations of employment programs for low-income populations. It complements a brief entitled “New Perspectives on Practice: A Guide to Measuring Self-Regulation and Goal-Related Outcomes in Employment Programs,” by Cavadel et al. (2018) that focuses on providing guidance to practitioners by encouraging them to consider self-regulation outcomes and by introducing measures of goal-related and self-regulation skills. This report focuses on providing guidance to researchers on how to measure self-regulation skills in evaluation settings, highlighting ways to address unique challenges that arise in this application. This report was written by Mathematica Policy Research and funded by the Office of Planning, Research, and Evaluation (OPRE) of the Administration for Children and Families (ACF) as part of the Evaluation of Employment Coaching for TANF and Related Populations.