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Key Findings:

• Wise Guys was well implemented and provided a meaningful supplement to the sexuality and reproductive health education typically offered in study schools.
• Compared to the standard school curriculum, Wise Guys did not change boys’ likelihood of sexual initiation after two years. On the two-year follow-up survey, only 1 in 10 boys reported ever having had sexual intercourse.
• The low overall rate of sexual activity limited the program’s potential effect during the study period, a common challenge for assessing the effects of teen pregnancy prevention programs serving a young population.
• The program did, however, increase boys’ knowledge of contraception and sexually transmitted infections, increased boys’ support for the view that sexually active youth should use condoms, and strengthened boys’ motivation to avoid getting someone pregnant.
• The program cost $488 per student served.