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来源类型Publication
Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits
Cornelius A. Rietveld; Dalton Conley; Nicholas Eriksson; Tõnu Esko; Sarah E. Medland; Anna A. E. Vinkhuyzen; Jian Yang; Jason D. Boardman; Christopher F. Chabris; Ben Domingue; David A. Hinds; Magnus Johannesson; Amy K. Kiefer; David Laibson; Patrik K. E. Magnusson; Joanna L. Mountain; Sven Oskarsson; Olga Rostapshova; Alexander Teumer; Joyce Y. Tung; Peter M. Visscher; Daniel J. Benjamin; David Cesarini; Philipp D. Koellinger; the Social Science Genetics Association Consortium
发表日期2014
出版者Psychological Science
出版年2014
语种英语
摘要

A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R 2 ≈ 0.02%), reached genome-wide significance (p < 5 × 10−8) in a large discovery sample and were replicated in an independent sample (p < .05). The study also reported associations between educational attainment and indices of SNPs called “polygenic scores.” In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large (N = 34,428) independent sample. We also found that the scores remained predictive (R 2 ≈ 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioral traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.

URLhttps://cepa.stanford.edu/content/replicability-and-robustness-genome-wide-association-studies-behavioral-traits
来源智库Center for Education Policy Analysis (United States)
资源类型智库出版物
条目标识符http://119.78.100.153/handle/2XGU8XDN/491659
推荐引用方式
GB/T 7714
Cornelius A. Rietveld,Dalton Conley,Nicholas Eriksson,et al. Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits. 2014.
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