This study examines the impacts arising from neuroscience and mental health research going back 20-25 years, and identifies attributes of the research, researchers or research setting that are associated with translation into patient benefit, in the particular case of schizophrenia.
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This report presents the full set of forward-tracing case studies.
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The study combined two methods: forward-tracing case studies to examine where scientific advances of 20 years ago have led to impact today; and backward-tracing perspectives to identify the research antecedents of today's interventions in schizophrenia. These research and impact trails are followed principally in Canada, the UK and the USA. The headline findings are as follows:
目录
Chapter One
Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size
Chapter Two
Synaptic modulation by dopamine of calcium currents in rat pars intermedia
Chapter Three
Differential distribution of GABAA receptor mRNAs in bovine cerebellum
Chapter Four
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
Chapter Five
PET scanning and schizophrenia
Chapter Six
Organisation of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntingdon's disease and schizophrenia
Chapter Seven
Auditory P300 in borderline personality disorder and schizophrenia
Chapter Eight
Elevation of human brain D2 dopamine receptors in schizophrenia
Chapter Nine
Expressed emotion research in London, UK, Chandigarh, India and Aarhus, Denmark
Chapter Ten
Northwick park study of outcomes following and characteristics prior to first schizophrenic episodes
Chapter Eleven
Low frontal glucose utilization in chronic schizophrenia: a replication study
Chapter Twelve
Using childhood home movies of adult schizophrenia patients to investigate the development of physical and behavioural abnormalities
Chapter Thirteen
Verapamil in the treatment of chronic schizophrenia
Chapter Fourteen
The effects of neuroleptics on lateralisation in schizophrenic patients
Chapter Fifteen
Specific and non-specific effects of educational intervention
Chapter Sixteen
Psychiatric morbidity of a long stay hospital population with chronic schizophrenia and implications for future community care
Chapter Seventeen
Randomised controlled trial of an inpatient family intervention for schizophrenia and affective disorders: the importance of gender in outcome and treatment response
