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Objective Analysis. Effective Solutions.

This study aimed to inform Hepatitis C (HCV) treatment by (1) better understanding the nexus of factors physicians consider when making HCV treatment decisions; (2) investigating the comparative influence and importance of specific factors and the trade-offs implicated in the decisionmaking process; and (3) examining how much thrombocytopenia impacts treatment decisions and how it impacts treatment.

To meet this goal, we conducted five analyses, focusing on four European countries characterised by different approaches to healthcare organisation and financing, which alongside cultural differences may have potential implications for treatment pathways for patients with HCV infection. These were: France, Italy, Spain, and the United Kingdom. These analysis included:

The five analyses build on one another, with the first three providing evidence that fed into the design of the DCEs and with the DCE results in turn serving as the key inputs into building the scenarios for the expert workshop.

• Chapter One

  Introduction

• Chapter Two

  Our methodological approach

• Chapter Three

  Literature review identifying the diversity of factors influencing treatment decisions

• Chapter Four

  Key informant interviews identifying and understanding the factors influencing treatment decisions

• Chapter Five

  Mapping patients' journeys for HCV treatment

• Chapter Six

  Using discrete choice experiments to quantify physicians' treatment decisions

• Chapter Seven

  Using scenario building to explore future potential situations

• Chapter Eight

  Conclusions

• Appendix A

  Literature review search strategy

• Appendix B

  Internal key informant interview guide (for interviewer)

• Appendix C

  Profile of interviewees

• Appendix D

  Workshop agenda

• Appendix E

  Full discrete choice experiment questionnaire