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来源类型 | Report |
规范类型 | 报告 |
DOI | https://doi.org/10.7249/RR2108 |
来源ID | RR-2108-OSD |
Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review | |
Margaret A. Maglione; Laura Raaen; Christine Chen; Gulrez Shah Azhar; Nima Shahidinia; Mimi Shen; Ervant J. Maksabedian Hernandez; Roberta M. Shanman; Susanne Hempel | |
发表日期 | 2018-10-30 |
出版年 | 2018 |
页码 | 273 |
语种 | 英语 |
结论 | A comprehensive literature search that screened over 6,000 research citations on the topic identified only 27 randomized controlled trials and ten observational studies that reported on functional outcomes
Evidence was mixed when MAT patients were compared with persons with OUD who were not on MAT
There was little statistically robust evidence that treatment effects systematically vary by medication
Direct comparisons of functional effects by route of administration, length of treatment, and treatment modality were scarce and reported mixed results and pointed to important research gaps that should be addressed in future studies |
摘要 | This systematic review addresses the question: What are the effects of medication-assisted treatment (MAT) that use buprenorphine, buprenorphine combined with naloxone, methadone, or naltrexone for opioid use disorder (OUD) on functional outcomes compared with wait-list, placebo, treatment without medication, any other comparator, or each other (e.g., buprenorphine versus naltrexone)? ,Functional outcomes investigated included cognitive (e.g., memory), physical (e.g., fatigue), occupational (e.g., employment status), social/behavioral (e.g., criminal activity), and neurological (e.g., balance) function. ,We searched five scientific research databases from inception to 2017 and reference mined existing reviews. Two independent literature reviewers screened 6,292 citations; 1,327 full-text publications were reviewed in detail and 37 studies met inclusion criteria. Critical appraisals assessed studies in detail, and quality of evidence was rated using established criteria. Results were synthesized in meta-analyses and presented in comprehensive evidence tables. Although MAT patients performed significantly better on some functional outcomes than persons with OUD who did not receive MAT, MAT patients performed worse on several cognitive measures than did matched "healthy" controls with no history of substance use disorder (SUD) or OUD. Because of the moderate-to-high risk of bias of most studies, quality of evidence is low or very low for all findings. ,The small number of studies reporting on outcomes of interest and the weaknesses in the body of evidence prevent making strong conclusions about MAT effects on functional outcomes. The literature shows that more research is needed that targets functional outcomes specifically, and there is, in particular, a lack of research evaluating potential differences in functional effects among medication types, the route of administration, treatment modality, and length of treatment. |
目录 |
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主题 | Military Health and Health Care ; Opioids ; Pharmaceutical Drugs ; Substance Use Disorder Treatment |
URL | https://www.rand.org/pubs/research_reports/RR2108.html |
来源智库 | RAND Corporation (United States) |
引用统计 | |
资源类型 | 智库出版物 |
条目标识符 | http://119.78.100.153/handle/2XGU8XDN/523663 |
推荐引用方式 GB/T 7714 | Margaret A. Maglione,Laura Raaen,Christine Chen,et al. Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review. 2018. |
条目包含的文件 | ||||||
文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
RAND_RR2108.pdf(3003KB) | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
1543953178071.jpg(6KB) | 智库出版物 | 限制开放 | CC BY-NC-SA | ![]() 浏览 |
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