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• Additional research is needed to develop a multiscale model of the human body, as well as the model's interaction with a blast wave.

This report describes what computational modeling reveals about the human body's immediate responses to blast trauma. Specifically, this literature review aims to (1) provide the state of the science of multiscale computational modeling of the human body's responses to blast-related trauma, including both descriptions of models used or developed and research findings, and (2) identify future opportunities to strengthen the current research on understanding the human body's responses to blast-related trauma particularly across multiple scales.

This review is meant to serve as a roadmap to inform additional computational and experimental research investigating the human body's responses to blast-related trauma. The most-valuable investigations will require an understanding of the interactions among cells, organs, and systems and how these interactions change in response to blast exposure over time.

Continued computational modeling of the human body's responses to blast exposure could better support service members, leading to improved personal protective equipment to reduce injury severity and improved care for those injured.

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