| 来源类型 | Working Paper |
| 规范类型 | 报告 |
| DOI | 10.3386/w7359 |
| 来源ID | Working Paper 7359 |
| The Diffusion of Science-Driven Drug Discovery: Organizational Change in Pharmaceutical Research | |
| Iain Cockburn; Rebecca Henderson; Scott Stern | |
| 发表日期 | 1999-09-01 |
| 出版年 | 1999 |
| 语种 | 英语 |
| 摘要 | Recent work linking the adoption of key organizational practices to productivity raises an important question: if adoption increases productivity so dramatically, why does adoption across an industry take so long? This paper explores this question in the context of one particularly interesting practice, the adoption of science driven drug discovery by the modern pharmaceutical industry. Over the past two decades, the established pharmaceutical industry has slowly shifted towards a more science-oriented drug discovery: (a) adopters experienced substantially higher rates of R&D after the late 1970s and (b) the rate of adoption across the industry was extremely slow. Motivated by the apparent contradiction between large boosts in performance and slow rates of adoption, this paper characterizes the sources of differences in rates of adoption between 1980 and 1993. The principal finding is that adoption of a science-oriented research approach was a function of initial conditions, or subject to 'state dependence': some firms simply began the sample period at a much higher level of science orientation. Moreover, while these effects attenuated over time, our empirical results suggest that it took more than ten years before adoption was unrelated to initial conditions. In addition, consistent with theories developed in the context of technology adoption, we find that relative diffusion rates depend on the product market positioning of firms. More surprisingly, adoption rates are seperately driven by the composition of sales within the firm. This latter finding suggests the potential importance of differences among firms in terms of the internal structure of power and attention, an area which has received only a small amount of theoretical attention. |
| 主题 | Microeconomics ; Households and Firms ; Industrial Organization ; Firm Behavior |
| URL | https://www.nber.org/papers/w7359 |
| 来源智库 | National Bureau of Economic Research (United States) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/564897 |
| 推荐引用方式 GB/T 7714 | Iain Cockburn,Rebecca Henderson,Scott Stern. The Diffusion of Science-Driven Drug Discovery: Organizational Change in Pharmaceutical Research. 1999. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| w7359.pdf（119KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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