| 来源类型 | Working Paper |
| 规范类型 | 报告 |
| DOI | 10.3386/w9615 |
| 来源ID | Working Paper 9615 |
| Productivity in Pharmaceutical Biotechnology R&D: The Role of Experience and Alliances | |
| Patricia M. Danzon; Sean Nicholson; Nuno Sousa Pereira | |
| 发表日期 | 2003-04-14 |
| 出版年 | 2003 |
| 语种 | 英语 |
| 摘要 | Using data on over 900 firms for the period 1988-2000, we estimate the effect on phase-specific biotech and pharmaceutical R&D success rates of a firm's overall experience, its experience in the relevant therapeutic category; the diversification of its experience, and alliances with large and small firms. We find that success probabilities vary substantially across therapeutic categories and are negatively correlated with mean sales by category, which is consistent with a model of dynamic, competitive entry. Returns to experience are statistically significant but economically small for the relatively straightforward phase 1 trials. We find evidence of large, positive, and diminishing returns to a firm's overall experience (across all therapeutic categories) for the larger and more complex late-stage trials that focus on a drug's efficacy. There is some evidence that a drug is more likely to complete phase 2 if developed by firms with considerable therapeutic category-specific experience and by firms whose experience is focused rather than broad (diseconomies of scope). Our results confirm that products developed in an alliance tend to have a higher probability of success, at least for the more complex phase 2 and phase 3 trials, and particularly if the licensee is a large firm. |
| 主题 | Health, Education, and Welfare ; Health ; Industrial Organization ; Firm Behavior |
| URL | https://www.nber.org/papers/w9615 |
| 来源智库 | National Bureau of Economic Research (United States) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/567239 |
| 推荐引用方式 GB/T 7714 | Patricia M. Danzon,Sean Nicholson,Nuno Sousa Pereira. Productivity in Pharmaceutical Biotechnology R&D: The Role of Experience and Alliances. 2003. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| w9615.pdf（229KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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