| 来源类型 | Working Paper |
| 规范类型 | 报告 |
| DOI | 10.3386/w23989 |
| 来源ID | Working Paper 23989 |
| Therapeutic Translation of Genomic Science: Opportunities and limitations of GWAS | |
| Manuel I. Hermosilla; Jorge A. Lemus | |
| 发表日期 | 2017-11-02 |
| 出版年 | 2017 |
| 语种 | 英语 |
| 摘要 | Many scientists predicted a swift revolution in human therapeutics after the completion of the Human Genome Project (“HGP”). This revolution, however, has been slow to materialize in spite of the scientific advances. We investigate the role of biological complexity in slowing down this revolution. Our test relies on a disease-specific measure of biological complexity, constructed by drawing on insights from Network Medicine (Barabási et al., 2011). According to our measure, more complex diseases are associated with a larger number of genetic mutations—higher centrality in the Human Disease Network (Goh et al., 2007). With this measure in hand, we estimate the rate of translation of new science into early-stage drug innovation by focusing on a leading type of genetic epidemiological knowledge (Genome-Wide Association Studies), and employing standard methods for the measurement of R&D productivity. For less complex diseases, we find a strong and positive association between cumulative knowledge and the amount of innovation. This association weakens as complexity increases, becoming statistically insignificant at the extreme. Our results suggest that biological complexity is, in part, responsible for the slower-than-expected unfolding of the therapeutical revolution set in motion by the HGP. |
| 主题 | Health, Education, and Welfare ; Health ; Industrial Organization ; Industry Studies ; Development and Growth ; Innovation and R& ; D |
| URL | https://www.nber.org/papers/w23989 |
| 来源智库 | National Bureau of Economic Research (United States) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/581658 |
| 推荐引用方式 GB/T 7714 | Manuel I. Hermosilla,Jorge A. Lemus. Therapeutic Translation of Genomic Science: Opportunities and limitations of GWAS. 2017. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| w23989.pdf（948KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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