| 来源类型 | Working Paper |
| 规范类型 | 报告 |
| DOI | 10.3386/w25526 |
| 来源ID | Working Paper 25526 |
| Understanding the Correlation between Alzheimer\u2019s Disease Polygenic Risk, Wealth, and the Composition of Wealth Holdings | |
| Su H. Shin; Dean R. Lillard; Jay Bhattacharya | |
| 发表日期 | 2019-02-11 |
| 出版年 | 2019 |
| 语种 | 英语 |
| 摘要 | We investigate how the genetic risk of developing Alzheimer's Disease (AD) relates to saving behavior. Using nationally representative data from the 1992-2014 Health and Retirement Study (HRS), we find that genetic predisposition for AD correlates with, but is not causally related to older individuals’ wealth holdings. People with higher Alzheimer’s Disease polygenic risk score (PGS) hold roughly 9 percent more wealth in CDs (hands-off assets) and around 11 percent, 15 percent, and 7 percent less wealth in stocks, IRAs, and other financial assets (hands-on assets) respectively. We explore three hypotheses that could explain these correlations. We hypothesize that people with high risk of AD choose different portfolios because: (i) they know their polygenic risk of developing Alzheimer’s Disease and related dementia, (ii) they have lower cognitive capacity, and (iii) the genome-wide association studies (GWAS) process that generated the Alzheimer’s Disease PGS failed to fully account for the aging process. Our extended model results do not support the first two hypotheses. Consistent with the third hypothesis, the interaction between age and the Alzheimer’s Disease PGS explains the correlation between genetic traits and asset holdings. |
| 主题 | Microeconomics ; Households and Firms ; Economics of Information ; Health, Education, and Welfare ; Health |
| URL | https://www.nber.org/papers/w25526 |
| 来源智库 | National Bureau of Economic Research (United States) |
| 引用统计 | |
| 资源类型 | 智库出版物 |
| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/583199 |
| 推荐引用方式 GB/T 7714 | Su H. Shin,Dean R. Lillard,Jay Bhattacharya. Understanding the Correlation between Alzheimer\u2019s Disease Polygenic Risk, Wealth, and the Composition of Wealth Holdings. 2019. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 资源类型 | 版本类型 | 开放类型 | 使用许可 | ||
| w25526.pdf（413KB） | 智库出版物 | 限制开放 | CC BY-NC-SA | 浏览 | ||
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