| 来源类型 | Working Paper
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| 规范类型 | 报告
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| DOI | 10.3386/w25670
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| 来源ID | Working Paper 25670
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| A Model of a Randomized Experiment with an Application to the PROWESS Clinical Trial |
| Amanda E. Kowalski
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| 发表日期 | 2019-03-18
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| 出版年 | 2019
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| 语种 | 英语
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| 摘要 | I develop a model of a randomized experiment with a binary intervention and a binary outcome. Potential outcomes in the intervention and control groups give rise to four types of participants. Fixing ideas such that the outcome is mortality, some participants would live regardless, others would be saved, others would be killed, and others would die regardless. These potential outcome types are not observable. However, I use the model to develop estimators of the number of participants of each type. The model relies on the randomization within the experiment and on deductive reasoning. I apply the model to an important clinical trial, the PROWESS trial, and I perform a Monte Carlo simulation calibrated to estimates from the trial. The reduced form from the trial shows a reduction in mortality, which provided a rationale for FDA approval. However, I find that the intervention killed two participants for every three it saved. [This paper has been combined with “Counting Defiers” (www.nber.org/ papers/w25671) and superseded by “Counting Defiers: Examples from Health Care” (https://arxiv.org/abs/1912.06739) as of July 17, 2020.] |
| 主题 | Econometrics
; Estimation Methods
; Public Economics
; Health, Education, and Welfare
; Health
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| URL | https://www.nber.org/papers/w25670
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| 来源智库 | National Bureau of Economic Research (United States)
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| 引用统计 |
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| 资源类型 | 智库出版物
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| 条目标识符 | http://119.78.100.153/handle/2XGU8XDN/583343
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推荐引用方式
GB/T 7714 |
Amanda E. Kowalski. A Model of a Randomized Experiment with an Application to the PROWESS Clinical Trial. 2019.
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文件名：
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w25670.pdf
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格式：
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Adobe PDF
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