G2TT
来源类型Working Paper
规范类型报告
DOI10.3386/w30084
来源IDWorking Paper 30084
Causal Inference During a Pandemic: Evidence on the Effectiveness of Nebulized Ibuprofen as an Unproven Treatment for COVID-19 in Argentina
Sebastian Calonico; Rafael Di Tella; Juan Cruz Lopez Del Valle
发表日期2022-05-30
出版年2022
语种英语
摘要Many medical decisions during the pandemic were made without the support of causal evidence obtained in clinical trials. We study the case of nebulized ibuprofen (NaIHS), a drug that was extensively used on COVID-19 patients in Argentina amidst wild claims about its effectiveness and without regulatory approval. We study data on 5,146 patients hospitalized in 11 health centers spread over 4 provinces, of which a total of 1,019 (19.8%) received the treatment. We find a large, negative and statistically significant correlation between NaIHS treatment and mortality using inverse probability weighting estimators. We consider several threats to identification, including the selection of “low” risks into NaIHS, spillovers affecting patients in the control group, and differences in the quality of care in centers that use NaIHS. While the negative correlation appears to be, broadly, robust, our results are best interpreted as emphasizing the benefits of running a randomized controlled trial and the challenges of incorporating information produced in other, less rigorous circumstances.
主题Health, Education, and Welfare ; Health ; Development and Growth ; Innovation and R& ; D ; COVID-19
URLhttps://www.nber.org/papers/w30084
来源智库National Bureau of Economic Research (United States)
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资源类型智库出版物
条目标识符http://119.78.100.153/handle/2XGU8XDN/587758
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GB/T 7714
Sebastian Calonico,Rafael Di Tella,Juan Cruz Lopez Del Valle. Causal Inference During a Pandemic: Evidence on the Effectiveness of Nebulized Ibuprofen as an Unproven Treatment for COVID-19 in Argentina. 2022.
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