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Natural regeneration is a cost-effective, nature-based tool for restoration that enhances resilience, supports local biodiversity, and supplies multiple ecosystem goods and services. However, for social, cultural and economic reasons, the potential of natural regeneration for achieving large-scale restoration objectives and climate mitigation targets is often overlooked. This information brief makes specific recommendations for policy changes that could enhance the role of natural regeneration in ecological restoration interventions and as an integral component of forest and landscape restoration.